Lithium carbonate
Lithium, Lithobid (lithium carbonate) is a small molecule pharmaceutical. Lithium carbonate was first approved as Lithobid on 1982-01-01. It is used to treat bipolar disorder, conduct disorder, depressive disorder, and post-traumatic stress disorders in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lithane | 2006-06-12 | |
| lithium | ANDA | 2024-11-05 |
| lithium carbonate | New Drug Application | 2024-10-09 |
| lithium carbonate extended release | 2007-03-30 | |
| lithium carbonate lithium carbonate | ANDA | 2022-11-24 |
| lithium lithium carbonate | New Drug Application | 2022-11-22 |
| lithobid | New Drug Application | 2022-10-28 |
Indications
FDA
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Agency Specific
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Clinical
Clinical Trials
416 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 7 | 13 | 43 | 47 | 32 | 137 |
| Depression | D003863 | — | F33.9 | 8 | 9 | 18 | 24 | 14 | 70 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 9 | 10 | 16 | 21 | 18 | 69 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 6 | 3 | 3 | 12 | 12 | 34 |
| Mania | D000087122 | — | — | — | 1 | 7 | 8 | 1 | 17 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 3 | 1 | 4 | 4 | 12 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | 3 | 1 | 3 | 6 | 12 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | 1 | 4 | 5 | 11 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | 1 | 3 | 3 | 8 |
| Wounds and injuries | D014947 | — | T14.8 | 2 | 3 | — | 1 | 3 | 8 |
Show 32 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Suicide | D013405 | — | — | — | 2 | 3 | — | 4 | 7 |
| Sclerosis | D012598 | — | — | 1 | 5 | 2 | — | — | 6 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | — | 4 | 2 | — | — | 5 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 4 | 2 | — | — | 5 |
| Attempted suicide | D013406 | EFO_0004321 | T14.91 | — | 2 | 2 | — | 2 | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 2 | — | 2 | 4 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | 2 | 3 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | — | — | 1 | — | 2 | 3 |
| Ataxia | D001259 | — | R27.0 | 1 | 2 | 1 | — | — | 3 |
| Spinocerebellar degenerations | D013132 | — | G11 | 1 | 2 | 1 | — | — | 3 |
Show 19 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | — | 4 | 5 | — | — | — | 6 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 2 | 5 | — | — | — | 5 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 2 | — | — | 1 | 4 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | 2 | 4 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 4 | 2 | — | — | — | 4 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 2 | 1 | — | — | 1 | 3 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | 2 | — | — | 1 | 3 |
| Shock | D012769 | — | R57.1 | — | 1 | — | — | 1 | 2 |
| Dysthymic disorder | D019263 | EFO_0008623 | F34.1 | — | 1 | — | — | 1 | 2 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | 1 | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | 1 | 2 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | 1 | — | — | — | 1 | 2 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | 1 | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| T-cell lymphoma | D016399 | — | — | 1 | — | — | — | 1 | 2 |
| Hodgkin disease | D006689 | — | C81 | 1 | — | — | — | 1 | 2 |
| B-cell lymphoma | D016393 | — | — | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 13 | 13 |
| Nonvital tooth | D019553 | — | — | — | — | — | — | 11 | 11 |
| Tooth discoloration | D014075 | — | K03.6 | — | — | — | — | 7 | 7 |
| Tooth fractures | D014082 | — | S02.5 | — | — | — | — | 7 | 7 |
| Prosthesis failure | D011475 | — | — | — | — | — | — | 5 | 5 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 4 | 4 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 4 | 4 |
| Dental implants | D015921 | — | — | — | — | — | — | 4 | 4 |
| Tooth loss | D016388 | — | — | — | — | — | — | 4 | 4 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lithium carbonate |
| INN | — |
| Description | Lithium carbonate is a lithium salt and a carbonate salt. It has a role as an antimanic drug. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C([O-])[O-].[Li+].[Li+] |
Identifiers
| PDB | — |
| CAS-ID | 554-13-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200826 |
| ChEBI ID | 6504 |
| PubChem CID | 11125 |
| DrugBank | — |
| UNII ID | — |
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Trends
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Safety
Black-box Warning
Black-box warning for: Lithane, Lithium, Lithium carbonate, Lithium carbonate lithium carbonate, Lithium lithium carbonate, Lithobid
Adverse Events
Top Adverse Reactions
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21,022 adverse events reported
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